Aid your weight loss goals with Amlexanox

Amlexanox is an anti-inflammatory and anti-allergic compound which has traditionally been used to treat ulcers by reducing healing time and pain.  It promotes fat loss by inhibiting the production of a specific enzyme in the body that is responsible for fat storage and inflammation.

Amlexanox is known to protect against bone disorders and liver disease. It can also help treat certain medical conditions like asthma due to its anti-allergic properties.

It has multiple mechanisms of action such as inhibiting inflammation by inhibiting the release of histamine and leukotrienes. It has been shown to selectively inhibit TBK1 and IKK-3, producing weight loss and improved insulin sensitivity.

It is through this mechanism that it has produced substantial results in terms of reducing HbA1C levels and increase insulin sensitivity. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are induced in liver and fat by NF-κB activation upon high-fat diet feeding and in turn initiate a program of counter-inflammation that preserves energy storage.

Amlexanox, an approved small-molecule therapeutic presently used in the clinic to treat aphthous ulcers and asthma, is an inhibitor of these kinases.

Treatment of obese mice with Amlexanox elevates energy expenditure through increased thermogenesis, producing weight loss, improved insulin sensitivity and decreased steatosis.