If your weight loss problem is less about metabolism and more about cravings that won’t quit, LDN targets the reward system driving that cycle.
You eat past fullness, you crave specific foods with real intensity, and your hunger signals don’t match what your body actually needs. That pattern is neurological, not motivational.
BEST FOR
Reducing food cravings and appetite
METHOD
Compounded oral capsule by mouth
FREQUENCY
Once daily before bedtime
LDN blocks β-endorphin action at opioid receptors, weakening the neurological reward signal from food. Patients consistently report less urgency around sugar, carbs, and calorie-dense foods.
LDN enhances leptin sensitivity, the hormone that signals satiety to your brain. You feel full sooner and more reliably, without the wired feeling that comes with appetite suppressants.
When cravings quiet down, willpower is no longer constantly depleted. Patients report choosing smaller portions and passing on snacks not because they are forcing it, but because the compulsive pull has genuinely weakened.
LDN modulates Toll-like receptor 4 signaling, reducing inflammatory responses in the nervous system. Chronic inflammation contributes to insulin resistance and weight gain, so this mechanism addresses both neurological and metabolic factors.
Naltrexone is an opioid receptor antagonist approved for treating opioid and alcohol dependence at 50mg. At low doses (1 to 5mg), it works through a different mechanism called transient opioid modulation.
A small nightly dose briefly blocks opioid receptors, prompting your body to upregulate endogenous opioids and receptor sensitivity. This rebound effect is what changes appetite signaling and reduces the reward response to food.
Our board-certified providers review your health history, current medications, and weight loss goals to determine whether LDN is appropriate for your situation.
Your prescription is compounded at licensed U.S. pharmacies, typically starting at 1.5mg and titrating upward to 4.5mg based on your tolerance and response.
LDN blocks β-endorphin at the μ-opioid receptor, preventing autoinhibition of POMC neurons that regulate satiety. Your appetite signals normalize within 2 to 3 weeks.
Your provider orders comprehensive lab work and your Personal Health Coach checks in regularly. We adjust dosing based on your craving patterns and weight loss progress.
Standard naltrexone (50mg) is a full opioid antagonist used for addiction treatment. Low dose naltrexone (1 to 5mg) creates a brief, transient receptor blockade that triggers your body to upregulate its own endorphins and opioid receptors. This rebound effect is what regulates appetite and cravings.
Most patients report noticeably reduced cravings within 2 to 3 weeks, with some noticing changes by week one. Weight loss itself is gradual and depends on your overall protocol, diet, and activity level. Your Personal Health Coach helps you track progress along the way.
The most common side effects during the first 1 to 2 weeks are vivid dreams, mild headache, and temporary sleep disruption. These typically resolve as your body adjusts. Our providers monitor your response at each check-in and adjust your dose if needed.
Not necessarily. Some patients reach their goals and maintain results after discontinuing LDN. Others use it longer-term for sustained appetite control. Your provider works with you to find the right timeline and adjusts your protocol as your needs change.
